Our Trip to Scotland & Ireland

Jeffrey and I took a trip to Scotland & Ireland from June 1 to June 22. We returned home on June 23. I took these photos with my brand new Android phone.

Scotland

We spent two weeks in Scotland (June 1 – June 14).

Portree, Isle of Skye

Portree is the largest town on, and capital of, the Isle of Skye in the Inner Hebrides of Scotland.

Cairngorms National Park

We visited a National park in Northeast Scotland that covers the Cairngorms mountain range and surrounding hills. The plant on the left is Scotch Broom, the horned animal in the center is a Highland Scottish cow (heilan coo), and the bird on the right is a pigeon.

Scara Brae Prehistoric Village in Sandwick, Stromness on the Orkney Islands

A 5,000 year old Neolithic village made of flagstone. It was uncovered by a storm in 1850.

Italian Chapel, Orkney Islands

This Roman Catholic Parish of Our Lady & St. Joseph is at Lamb Holm in the Ornkey Islands. It was built during WWII by Italian prisoners of war. The chapel was completed after the end of the war and restored in the 1960s and 1990s. Mass is held in the chapel on the first Sunday of the summer months (April–September).

Orkney Island Coastline

Gorgeous!

Ring of Brodgar, Orkney Island

The Ring of Brodgar is a Unesco World Heritage site and one of the largest Neolithic stone circles in Britain. The little sheep was sleeping outside the ring near his mama and some other sheep.

Conon Bridge Hotel Carpet

A plaid carpet! Don’t think it was made by Harris Tweed, but it sure was fun walking up and down from our room to the dining room.

Harris Tweed Shop in the Hebrides, Isle of Lewis

We visited the Harris Tweed factory in the Hebrides. Top row left is the Griffith Rappier Mark I, top row right is the Griffith Rappier Handloom. Bottom row right is a pair of tweed shoes. Harris Tweed means a tweed that has been hand loomed by islanders at their homes in the Outer Hebrides, and made from pure virgin wool dyed and spun in the Outer Hebrides.

Sheep and Sand Designs on the Coast in the Hebrides, Isle of Lewis

Sheep are everywhere in Scotland. So cute! Bottom row are designs left by the sea on a beautiful seashore.

Callanish

The Neolithic Callanish stones are about 5,000 years old. They are in the village of Callanish on the west side of the Isle of Lewis in the Outer Hebrides.

Talisker and Sligachan

On the beautiful Isle of Skye in Northern Scotland, we went on a nice walk to the beach, and on the way back, we met these sweet peacocks. The flowers are pretty too.

Ireland

We spent one week in Ireland (June 16 – June 22).

Dublin

We went to Trinity College to visit the Old Library there. To get into the Old Library, you have to go through an exhibit of the Book of Kells. The Book of Kells is a beautifully illuminated text that presents the four Gospels in Latin based on the Vulgate text that St Jerome completed in 384AD. There are also readings from the earlier Old Latin translation. I don’t have any photos of the Book of Kells, but I was able to photograph the Trinity College Old Library and some of the old books on exhibit there.

We were very lucky to even get into the Book of Kells exhibit. When we got to the ticket booth, the nice Italian man selling the tickets said they were sold out for the rest of the day. We hung around a bit and had a very fun conversation with him, and then he suddenly said two tickets had become available, and that we could have them if we wanted them. Of course we wanted them!

Kerry County Coastline and Flowers

The purple flowers on the top-right are heather. They were starting to bloom all over Scotland and Ireland while we were there.

Somewhere between Dublin and Clifden

We stopped at a wildlife hide in the countryside between Dublin and Clifden. A wildlife hide is a small building with windows and a bathroom in the wilderness where photographers can hang out and photograph wildlife without being seen and without scaring the wildlife away. I preferred to take a walk and took the following photos.

Lough Leane, Kerry County

We hiked the trail through the trees along the beautiful waterfall, and visited the lake with ducks and deer, and a castle that I didn’t get a photo of.

Kinvarra, Galway

Kinvarra (Cinn Mhara, meaning ‘head of the sea’) is a pretty seaport village in the southwest area of Galway. We visited Dungaire Castle, and on the way out stopped to listen to a singing group playing traditional instruments.

The couple on the far right are Carol and Roy from Wisconsin. They were our travel partners for the Ireland trip.

Kylemore Abbey and Clifden Scenic View in Galway

The Benedictine Monastery, Kylemore Abbey , was founded in 1920 on the grounds of Kylemore Castle. It was founded for Benedictine nuns who fled Belgium in WW1. It is in Connemara, County, Galway, Ireland. The next photo is the view from Sky Road scenic drive, which is near Clifden in Galway County.

Our Trip to Scotland & Ireland

My Experience with Hormone Testing

A lot of people probably know about hormone-sensitive cancers (breast, uterine, ovarian, testicular), but maybe not as much about how hormone testing can provide insight into your potential risk for them and other hormone-related diseases. I’ve been using the Complete Hormones test offered by Genova Diagnostics mainly because the presentation is relatively easy to follow, and my health insurance covers it. Another popular hormone test is the Dried Urine Test for Comprehensive Hormones (DUTCH).

In this post, I discuss the Genova Complete Hormones first morning void test. The PDF with the test results is 4-1/2 pages of bar charts, diagrams, a pie chart, and 4-1/2 pages of commentary. The first time you see the test results and read through the commentary can be daunting because there is a lot of information expressed in technical terms that many people who are not doctors or scientists might find unfamiliar or intimidating.

A discussion with the ordering doctor is very helpful in interpreting the results, but you can use the information in this post to familiarize yourself with your results beforehand and go prepared with questions, and perhaps impress your doctor with your keen insights.

Note: If anyone reading this can provide input, corrections, additional information, or better explanations, please add your input to the comments section. Thank you very much! 

Test Results

The Genova Test results are broken into the following main headings, which present the test results in different formats and cover a range of hormone-related topics. The idea is to get comprehensive results, and if any potential issues are noted, dive deeper into them with your physician or specialist.

  1. Steroidogenic Pathway At-A-Glance
  2. Interpretation At-A-Glance
  3. Progesterone
  4. Androgens
  5. Glucocorticoids
  6. Estrogens

I used example test results for the following discussions from a sample test that I downloaded from the Genova website. The sample test I used is available for download on the Complete Hormones page in the column on the right.

Note: The very last section in this post, The Effect of Estrogens and Androgens on Glucocorticoids, is not part of the test so it's not in the numerated list above. It is a few extracts from an interesting article that explains the relationship between androgens and glucocorticoids (anabolic/catabolic balance) including estrogens. Estrogens are androgen metabolites. The Complete Hormones test includes estrogens, but does not include them in the anabolic/catabolic balance sections.

Ratios

As you go through the discussions in this post, you will find ratios in several places. Ratios provide information that can further clarify data and help to inform discussions with your doctor. Ratios appear in the following places with descriptions in this blog post:

  • A section called Ratios under Estrogens
  • Several ratios in the Interpretation At-A-Glance section under Enzymatic Activity
  • One ratio in the Glucocorticoids section (allo-Tetrahydrocortisol (a-THF))

How to Increase Hormone Methylation

When you go through your own test results, you might learn that you need to improve your hormone methylation. Information about how to do that is in this post under Supplements to Reduce Breast Cancer Risk.

1. Steroidogenic Pathway At-A-Glance

Steroidogenesis is a multistep process where your body biosynthesizes steroid hormones from cholesterol to produce steroids that your body uses. The first steroid hormone synthesized from cholesterol is pregnenolone, and so pregnenolone is the first hormone shown in the top-left corner in the Steroidogenic Pathway At-A-Glance section on page 1 of the test results.

Pregnenolone is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids.

-Wikipedia
Screen shot from Genova sample test reproduced by permission of Genova Diagnostics 3/2022.

The At-A-Glance page is separated into shaded sections with titles in small bold type and different background colors to indicate groupings. The sections include arrows that show the flow of enzymatic biosynthesis from one steroidal hormone to another, and from one grouping to another. These flows are referred to as pathways. You could say, for example, that androgens are synthesized from pregnenolone through the 17-OH-Pregnenolone pathway, and synthesized from progesterone through the 17-OH-Progesterone pathway.

There is a key in the lower-left corner that explains the notations along the arrows. As an example, you would read the upper-left corner of the Steroidogenic Pathway At-A-Glance page as follows:

  • Pregnenolone uses the 3βHSD enzyme to synthesize progesterone
  • Progesterone excretes pregnanediol
  • Progesterone uses the CYPc21 enzyme to synthesize Corticosterone (a mineralcorticoid)
  • Progesterone uses the CYPc17 enzyme to synthesize 17-OH-Progesterone (a glucocorticoid)

The small rectangles with the pink ends and green middles summarize the steroidal hormone values, whether they are in the normal range (green) or too high or too low (pink right and pink left), and include the reference ranges for each one.

Glucocorticoid and Mineralcorticoid Hormones

Glucocorticoid hormones (against the pink background) are catabolic hormones produced in the adrenal cortex. Catabolic means they break down complex molecules such as proteins or lipids (fats) to release energy. Elevated glucocorticoid hormones are often associated with stressful events. The most common glucocorticoid hormone in humans is cortisol.

Mineralocorticoids (against the orange background) are also catabolic hormones produced in the adrenal cortex. They regulate sodium, chlorine, and potassium concentrations in extracellular fluid to control fluid status, electrolyte concentration, and potassium in your body.

Androgen Hormones

Androgen hormones are anabolic, which means they promote communication between cells around your entire body. In women, androgens are produced in the ovaries, adrenal glands, and fat cells. In men, androgens are primarily produced in the testes, and secondarily produced in the adrenal glands.

Anabolic/Catabolic Balance

Anabolic and catabolic hormones are primarily evaluated according to an anabolic to catabolic ratio, which is shown on the next page of the results and discussed under Interpretation At-A-Glance below.

Estrogen Metabolites

Estrogen metabolites are metabolized from androstenedione and testosterone, which are androgens. Men produce two primary types of estrogen: estrone (E1) and estradiol (E2). Men also produce estriol (E3), but in very low amounts. Women produce the same 3 types of estrogen, but in much higher amounts.

In men estrogens help process muscle mass, preserve bone strength, protect against cardiovascular disease, maintain healthy skin, and promote healthy brain function, among other things. For a better understanding of how estrogen affects men’s health, see The Role of Estrogen in Men’s Health.

In women estrogens perform the same functions as they do in men, plus more:

  • Estradiol (E2) is the most common estrogen in women of childbearing age. It is used in hormone replacement therapy (HRT) for post-menopausal women and is the most potent estrogen of the three. Its main function in a woman’s body is to mature and maintain the reproductive system. It is also important for healthy brain function.
  • Estriol (E3) is the main estrogen during pregnancy. It is much less potent than estradiol. It promotes uterine growth and prepares a woman’s body for giving birth.
  • Estrone (E1) is the only estrogen a woman’s body makes after menopause. It is much less potent than either estradiol or estrone. A woman’s body can metabolize estrone into estradiol.

Estradiol is required for many other biological functions in addition to its role in (male and) female reproductive processes. In fact, this versatile hormone regulates sexual differentiation of the brain and provides protective effects for the bones, brain, and cardiovascular system.

Estradiol and the Brain

Estrogen metabolites are produced in two phases: 1) hydroxylation, and 2) methylation (detoxification). Looking at the Estrogen Metabolism section in the above graphic, you can see that estradiol is converted to estrone (E1), and then there are 3 different pathways through which estrone (E1) is methylated by means of the indicated enzymes.

2-OH(E1+E2) aka 2-Hydroxy is the 2 methylation (detoxification) pathway. It is considered to be the optimal pathway for hormone metabolism because its metabolites (2-MeO (E1+E2)) provide anti-cancer activity for multiple types of cancers. However, some studies suggest that a predominance of the 2-hydroxy pathway can accelerate postmenopausal bone loss when compared to men and women who predominately use the 16α-hydroxy pathway.

16α-OH(E1) aka 16-Hydroxy is the 16 methylation (detoxification) pathway. It is important for bone formation, is the precursor to estriol (E3), and has been indicated in hormone-related cancer risk in some studies. This pathway is both good and possibly pro-cancer.

4-OH(E1+E2) aka 4-Hydroxy is the 4 methylation (detoxification) pathway. According to studies, this pathway is associated with greater risk for hormone-related cancers, such as breast cancer. When the 4-Hydroxy metabolites are not fully methylated by 4MeO(E1+E2), they build up, and your body converts the build-up to 3,4-Quinones (free radicals), which are considered to be potent carcinogens.

I came across an interesting study where it appears that if a woman is Chinese that whether she is premenopausal or postmenopausal can make a difference in the cancer risks associated with the detoxification pathways:

Urinary concentration of estrogen metabolites 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestradiol (4-OHE2), 4-methoxyestrone (4-MeOE1), and 16α-hydroxyestrone were lower in postmenopausal patients with breast cancer, compared with benign controls. In logistic regression model, breast cancer risk increased with the decline in the levels of 4-OHE2 and 4-MeOE1. In premenopausal patients, a difference in the level of 2-OHE2 was observed between both groups, and 2-OHE2 was found to have predictive value for breast cancer. Additionally, urinary 2-OHE2 level in premenopausal hormone receptor positive (HR+) patients was considerably higher compared with hormone receptor negative patients.

Urinary estrogen metabolites and breast cancer risk in Chinese population

Here is another study that focused on personal and lifestyle habits and their effects on breast cancer risk:

Our findings suggest that BMI, race/ethnicity, and some reproductive and lifestyle factors may contribute to postmenopausal BCa (breast cancer) through their effects on circulating estrogens.

Associations of established breast cancer risk factors with urinary estrogens in postmenopausal women

For more information about the methylation pathways, see:

COMT Gene and Enzyme

In the Estrogen Metabolites section, the Catechol-O-Methyltransferase (COMT) enzyme appears in the 2OH(E1+E2) methylation line and in the 4OH(E1+E2) methylation line. The COMT gene produces the COMT enzyme, as described in the following quote from MedlinePlus – COMT Gene:

The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase (COMT). Two versions of this enzyme are made from the gene. The longer form, called membrane-bound catechol-O-methyltransferase (MB-COMT), is chiefly produced by nerve cells in the brain. Other tissues, including the liver, kidneys, and blood, produce a shorter form of the enzyme called soluble catechol-O-methyltransferase (S-COMT). This form of the enzyme helps control the levels of certain hormones.

The soluble form of the COMT enzyme initiates the estrogen methylation that results in the methoxy estrogens, 2-MeO and 4-MeO, which are the metabolites of 2OH(E1+E2) and 4OH(E1+E2).

References

2. Interpretation At-A-Glance

The next page titled Interpretation At-A-Glance provides bar charts and a pie chart for anabolic/catabolic balance, enzymatic activity, and estrogen metabolism.

Screen shot from Genova sample test reproduced by permission of Genova Diagnostics 3/2022.

Anabolic/Catabolic Balance refers to the balance between growth and healing (anabolic) and wear and tear (catabolic) activity in the body. Both anabolic and catabolic metabolism are essential to health. Too much catabolic activity in relation to anabolic activity can indicate stress.

For more information about anabolic/catabolic balance and the role of estrogen, see:

Enzymatic Activity and Estrogen Metabolism

The bar charts in the Enzymatic Activity section provide ratios for the Estrogen Metabolism information shown in the pie chart.

Screen shot from Genova sample test reproduced by permission of Genova Diagnostics 3/2022.

Under Enzymatic Activity (Ratios):

  • 2-OH (E1+E2) /16α-OHE1 is the ratio for decreased cancer risk estrogen metabolism compared to (/) pro-bone & increased cancer risk estrogen metabolism. In older studies, a lower 2/16 ratio indicated more breast cancer risk particularly for premenopausal women. However, recent studies have not strongly correlated a higher 2/16 ratio with protection against breast cancer in premenopausal or postmenopausal women.
  • 2-OH (E1+E2) /2-MeO (E1+E2) is the decreased cancer risk estrogen metabolism compared to (/) decreased cancer risk estrogen methylation ratio. In this example, the ratio is lower than normal indicating more than normal estrogen methylation. A high ratio indicates less estrogen methylation and points to the possible presence of estrogen dominance and breast cancer risk. A low to normal ratio is associated with decreased breast cancer risk due to an increased concentration of the 2-MeO metabolite, which is considered to be effective against multiple hormone-related cancers.

Under 5α-Reductase Activity (Ratios):

5α-Reductase activity (5AR) is calculated as the ratio of etiocholanolone to androsterone (E/A) ratio. The ratio provides an assessment of how well your body is metabolizing dihydrotestosterone (DHT) from testosterone. A low ratio means your body is producing more DHT from testosterone resulting in a more androgenic metabolism. See Clinical Significance of 5α-reductase activity.

  • Etiocholanolone is a DHEA metabolite, and androsterone is a by-product of androgen breakdown.
  • Dihydrotestosterone (DHT) is a metabolite of testosterone, and is estimated to be three to six times more powerful than testosterone. Both hormones are classified as androgens. DHT is mainly created in the organs where it is used, such as the prostate. The 5α-Reductase enzyme is primarily responsible for converting testosterone to DHT. For more information, see What Is Dihydrotestosterone (DHT)?

Under Estrogen Metabolism:

The pie chart shows the quantities of the different estrogen metabolites in 3 groupings by color. Green indicates less risk for hormone-related cancers, pink indicates more risk, and yellow indicates mixed findings regarding risk. Note that the 4-MeO(E1+E2) slice is a lot smaller than the 4-OH(E1+E2) slice. This indicates that there is less 4-OH methylation happening, which causes 4-OH to build up (a lot of pink in the pie chart) and potentially increase breast cancer risk.

Supplements to Reduce Breast Cancer Risk

The following supplements can stimulate the COMT enzyme and hormone methylation to help reduce hormone-related cancer risk, and possibly shift more hormone methylation to the 2-OH pathway:

  • S-Adenosyl-l-Methionine (SAMe)
  • Methionine
  • Magnesium
  • Vitamins B2, B6 and B12 (methylated versions work best)
  • Folate or folinic acid, 5-formyl THF, 5-methyltetrahydrofolate
  • Trimethylglycine (TMG)
  • Glutathione
  • Stress management to reduce catecholamine production
  • DIM for hormone balance and to stimulate antioxidant activity to prevent free radical damage

Low methylation can be caused by low levels of nutrients needed for methylation and/or genetic abnormalities (COMT, MTHFR). The COMT enzyme responsible for methylation requires magnesium and methyl donors. Deficiencies in folate or vitamin B6 or B12 can cause low levels of methyl donors . MTHFR genetic defects can make it more difficult for patients to make sufficient methyl donors . Genetic defects in COMT can make methylation poor even in the presence of adequate methyl donors.

DUTCH-Sex-Hormones-Female-Sample-Report

3. Progesterone – Pregnanediol

On the next page, the metabolite listed at the top under progesterone, is pregnanediol. The metabolite value shown is used to evaluate and inform decision making in women who have difficulty becoming pregnant or tend to miscarry. It is also used to monitor high-risk pregnancies.

Screen shot from Genova sample test reproduced by permission of Genova Diagnostics 3/2022.

The amount of pregnanediol and pregnanetriol found in urine can be used to assess progesterone levels in the body. Pregnanetriol is a glucocorticoid metabolite of 17-OH-Progesterone. For more information see a-Pregnanediol (luteal range).

Androgens

The Androgens section presents the results for the 17-ketosteroids category of metabolites, plus testosterone and androstanediol. Androgen hormones are anabolic, which means they promote communication between cells around the entire body. Estrogens are androgen metabolites, and their results are shown under Estrogens and Estrogen Metabolites after the Androgens section.

Screen shot from Genova sample test reproduced by permission of Genova Diagnostics 3/2022.

Testosterone and DHEA are hormones released by the testes in males, and by the adrenal glands in males and females. They are rapidly metabolized into 17-ketosteroids, which are substances that form as your body breaks down androgens (anabolic sex hormones).

The overall total for DHEA, testosterone, and the 17-ketosteroids provides a more accurate idea of your overall androgen production and androgen activity. For more information, see 17-Ketosteroids, Total (FMV urine, menopause).

Androsterone and Etiocholanolone are DHEA metabolites that are metabolized through Androstenedione and the 5α- and 5β-reductase pathways. These androgens enable assessment of 5α-reductase activity. Elevated 5α-reductase activity is associated with obesity and insulin resistance in both men and women. For more information see Androsterone (FMV urine, menopause), Etiocholanolone, and Clinical Significance of 5α-reductase activity.

Glucocorticoids

The Glucocorticoids section presents the results for the 17-hydroxysteroids metabolites category. Glucocorticoid hormones are catabolic hormones produced in the adrenal cortex. Catabolic means they break down complex molecules such as proteins or lipids (fats) to release energy.

Screen shot from Genova sample test reproduced by permission of Genova Diagnostics 3/2022.

Pregnanetriol is metabolized from progesterone. Urine levels of pregnanetriol and pregnanediol metabolites can be used to assess the amount of progesterone in the body. Pregesterone deficiency is associated with various PMS conditions such as headaches, insomnia, cancer, cysts, and more. Progesterone deficiency in men has symptoms similar to testosterone deficiency. For more information, see Pregnanetriol (FMV urine).

allo-Tetrahydrocortisol (a-THF) is the ratio of active cortisol to inactive cortisone metabolites. Imbalances towards active cortisol or inactive cortisol can lead to various conditions. A low result might indicate hypothyroidism, anorexia, or impaired liver function. A high result might indicate that your insulin is too high (insulin resistance) or your thyroid is overactive (hyperthyroidism). See a-Tetrahydrocortisol (a-THF) for more information.

The 17-Hydroxysteroid total consists of a-THF plus the other 3 cortisone metabolites (tetrahydrodeoxycortisol, tetrahydrocortisone, and tetrahydrocortisol). When the 17-Hydroxysteroid total is high over a long period of time, it is an indicator of stress or possibly hypercorticolism (Cushing syndrome). For more information, see What is Hypercortisolism? If your 17-Hydroxysteroid total is high, you might want to consider adopting stress reduction activities, seeing a doctor, or both.

Estrogens and Estrogen Metabolites

The estrogens and estrogen metabolites page is the Estrogen Metabolite information from the Sterioidogenic Pathway At-A-Glance page. In this section, the information is presented in bar charts and includes ranges for premenopause, menopause, and males for each estrogen and metabolite. Note that there is no metabolite for 16a-OHE2 because it is the precursor to Estriol (E3), which is one of the 3 estrogens.

If you are a woman on hormone replacement therapy (HRT), you should discuss your results with your doctor to work out where your estrogen levels should be. Others can go by the premenopause, menopause, and male ranges provided for each bar chart.

For more information about HRT, see:

Screen shot from Genova sample test reproduced by permission of Genova Diagnostics 3/2022.
Screen shot from Genova sample test reproduced by permission of Genova Diagnostics 3/2022.

Ratios

Ratios can provide more information about hormone-related cancer and osteoporosis risks. Keep in mind that this topic needs further study, and therefore, at best indicates associations, and not direct causes.

Screen shot from Genova sample test reproduced by permission of Genova Diagnostics 3/2022.

Anabolic/Catabolic balance indicates whether your body’s anabolic and catabolic functions are in balance, or tipped more towards growth and healing (anabolic) or more towards wear and tear (catabolic). Your body needs to rebuild and repair (anabolism), but also requires enough corticosteroids to respond to stressors and discharge cellular toxins (catabolism). If your ratio is too low or too high, you should work with a doctor to find out what, if any, underlying condition might be the cause.

  • High ratio (in the pink to the right): Indicates a lot of anabolic activity, which might be associated with acne, prostatism, metabolic syndrome, and other conditions.
  • Low ratio (in the pink to the left): Indicates a lot of catabolic activity, which might be associated with aging, insomnia, chronic stress, chronic illness, diabetes, and other conditions.

E/A: 5ß/5a Ratio indicates how well your body metabolizes DHT from testosterone. It is the ratio of etiocholanolone to androsterone (E/A). A low ratio (in the pink to the left) means your body is producing more DHT from testosterone (more androgenic).

2-OH (E1+E2) /16α-OHE1 is the ratio for decreased cancer risk estrogen metabolism compared to (/) pro-bone & increased cancer risk estrogen metabolism. In older studies, a lower 2/16 ratio (in the pink to the left) indicated more breast cancer risk particularly for premenopausal women. Recent studies have not strongly correlated a higher 2/16 ratio with protection against breast cancer in premenopausal or postmenopausal women. A higher ratio (in the pink to the right) in males has been associated with reduced risk of prostate cancer.

Some studies show that a significant number of women who predominantly use the 2-OH pathway have accelerated postmenopausal bone loss and a lower BMD compared to women who predominantly use the 16a-OH pathway. Inherited differences in estrogen metabolism might put women who predominantly use the 2-OH pathway at higher risk for bone loss.

2-OH (E1+E2) /2-MeO (E1+E2) is the decreased cancer risk estrogen metabolism compared to (/) decreased cancer risk estrogen methylation ratio. In this example, the ratio is lower than normal (in the pink to the left) indicating more than normal estrogen methylation.

A high ratio (in the pink to the right) indicates less estrogen methylation and points to the presence of estrogen dominance and breast cancer risk.

A low to normal ratio is associated with decreased breast cancer risk due to an increased concentration of the 2-MeO metabolite, which is considered to be effective against multiple hormone-related cancers.

For information about how to use supplements to increase hormone methylation, see Supplemements to Reduce Breast Cancer Risk in this document.

The Effect of Estrogens and Androgens on Glucocorticoids

The following text is extracted from Do the interactions between glucocorticoids and sex hormones regulate the development of the metabolic syndrome? by Faculty of Biology, Department of Nutrition and Food Science, University of Barcelona. The excerpts and the original article are free to read and use for non-commercial use.

Estrogens decrease inflammation and reduce the glucocorticoid response. Low estrogen (infancy, menopause) again allow the predominance of glucocorticoids and the manifestation of the metabolic syndrome. It is postulated that the equilibrium between sex hormones and glucocorticoids may be a critical element in the timing of the manifestation of metabolic syndrome-related pathologies.

Metabolic Syndrome is a group of conditions that increase your risk of heart disease, stroke, and type 2 diabetes. The conditions occur simultaneously and include the following: increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels.

Androgens limit the operation of glucocorticoids, which is also partly blocked by estrogens, since they decrease inflammation (which enhances glucocorticoid release). These facts suggest that the appearance of the metabolic syndrome symptoms depends on the strength (levels) of androgens and estrogens.

Legend:
HPA Axis: Hypothalamic-pituitary-adrenal Axis
HPG Axis: Hypothalamic-Pituitary Gonadal Axis
My Experience with Hormone Testing

Natural Ways to Improve Bone Health

Bone loss is very common, especially in older people, and for many people, adding exercise and bone-healthy nutrition from food and/or supplements can help or cure the problem.

However, in addition to diet and exercise, you should find out if you have any medical issues that can interfere with your body’s bone-making process. If you do, the nutritional and exercise advice provided here can certainly help, but you might not be able to achieve normal or near normal bone density.

Ask your doctor to order the following tests to pinpoint medical issues that interfere with the bone making process:

1. Urine test for calcium: Calcium Urine, Timed to find out if you are getting enough calcium. When your body needs calcium and you are not getting enough in your diet or by supplementation, it takes the calcium from your bones and puts it into your blood. A normal or great blood test for calcium levels can be covering up that you are not getting enough calcium to maintain healthy bones.

2. Parathyroid gland test: The parathyroid gland keeps your calcium levels balanced. If the parathyroid hormone becomes imbalanced, your bones can become weak and porous, which results in low bone density.

3. Calcitonin test: Your body makes the calcitonin hormone in the thyroid gland. It’s role is to help regulate calcium levels in your blood by increasing and decreasing the calcium levels to manage the bone remodeling process.

Additional tests can include CBC (complete blood cell) and vitamin D3 levels.

Proton Pump Inhibitors

Proton pump inhibitors (PPIs), can interfere with the bone remodeling process too and result in low bone density and increased fracture risk. If you want to know more, read:

“Healing Heartburn Naturally – A Guide to Managing Acid Reflux and Restoring Gut Health” by Dr. Tieraona Low Dog, MD.

Her book offers a lot of information on how to safely taper off acid-suppressing medications and strategies for optimizing health after long-term PPI use. She also covers how to stay healthy while takking PPIs if long-term PPI use is necessary.

Our body’s bone remodeling process is very involved. In my opinion, I think that is why bone drugs that target a particular aspect of the bone making process don’t work very well for most people and have so many possible side effects.

Your body knows exactly what to do with nutrients like calcium, magnesium, and D3, but drugs are foreign substances. They can do some good, but typically only help a little and can have bad side effects. You also have to stop taking them or change to another drug after a few years.

I think the natural approach is worth trying, and should be tried with weight-bearing exercise before you resort to drugs. Even if it doesn’t help your bones because you have a problem in your thyroid or parathyroid glands, the natural approach will, at the very least, leave you in better bone health and better overall health.

This is why I think the natural approach is worth trying, and should be tried before resorting to drugs. Even if it doesn’t help your bones because you have a problem in your thyroid or parathyroid glands, the natural approach will, at the very least, leave you in better health. The natural approach has no side effects (except maybe if you have food allergies), and if you make it a lifestyle change, then any improvement you get could last your lifetime.

Nature vs. Bone Drugs

One thing I have learned in my journey from diseased to healthy bones is that our body’s bone remodeling process is very intricate. In my personal opinion, I think that is why bone drugs that target a particular aspect of the bone making process don’t work very well and have so many side effects.

Your body knows exactly what to do with nutrients like calcium, magnesium, and D3, but drugs are foreign substances. They can do some good, but they might only help a little and can have unwanted side effects. You also have to stop taking them or change to another drug after a few years.

This is why I think the natural approach works much better, and should be tried with weight bearing exercise before you resort to drugs. Even if it doesn’t help your bones because you have a problem in your thyroid or parathyroid glands, the natural approach will at the very least leave you in better health. The natural approach has no side effects (except maybe if you have food allergies), and if you make it a lifestyle change, then the improvement will likely last for your lifetime.

If you want to be really, really thorough with testing, here is a very comprehensive list of tests for assessing bone health put together by Dr. Keith McCormick, Chiropractor:

*

Keep reading for detailed information bone nutrition and weight bearing exercise options. There are all important if you want to build and maintain strong, healthy, non-osteoporotic bones without bone drugs.

In this document
Nutrients for Bone Building
Estrogen
Chinese Herbs for Menopause Support
Exercise
Yoga
Qi Gong and Tai Chi
Yoga Sequences for Bone Health

The following sections walk through everything that I know that you can do to improve your bone density short of taking bone drugs.

Nutrients for Bone Building

While a lot of people might think they need more or better weight-bearing exercise if they have low bone density, that isn’t always the case.

Exercising, no matter how much, won’t help you build bone density if your body either 1) doesn’t have the right nutrients to do the job, or 2) has something wrong in the thyroid or parathyroid glands that would inhibit the bone remodeling process. See my first post for more information about testing the parathyroid and thyroid gland. As far as nutrients go, it doesn’t matter to your body if you take supplements, or get the nutrients from your food, or a combination.

Bone remodeling is the continuous process by which your body removes old bone tissue from and adds new bone tissue to your skeleton. The bone remodeling process requires that specific nutrients be available in your body to help maintain a balanced activity of bone remodeling. If there is a lack of any of these nutrients or some other imbalance in the bone remodeling cycle, the strength, flexibility, and integrity of your bones will degrade over time.

Bone tissue is about 70% mineral content and 30% organic matter:

  • Mineral portion: 95% is calcium hydroxyapatite, and the rest is sodium, magnesium, fluoride, and strontium. Hydroxyapatite is a calcium and phosphorus compound found in teeth and bone.
  • Organic portion: 98% is collagen fibers, and the remaining 2% is a supporting matrix of glycoproteins and proteoglycans.  

I recommend the forces that yoga generates – doing Series I every day at least once – and 40+ grams of protein, 1500 mg. of calcium, 1500 IU of vitamin D3, 250 – 400 mg of magnesium and 90 mcg of vitamin K2, all daily. Please don’t overdo the protein, too much can harm the kidneys, but 50 – 175 grams a day will stand you in good stead with a 2000 calorie diet.

– Dr. Fishman from his newsletter.

Calcium

Besides being the primary mineral in your bones, calcium is also important for muscle contraction, nerve conduction, and intracellular signaling.

Calcium metabolism has a direct influence on whether your body removes old bone from your body and adds new bone. This bone remodeling process is regulated by the interplay between parathyroid hormone (PTH), which stimulates bone resorption; and calcitonin, a hormone that reduces calcium in the blood. Also, factors such as genetics, hormones, physical activity, and nutrition, influence whether your body removes old bone and adds new bone. A drop in the calcium level in your blood triggers the removal of old bone, which can result in a decline of bone-mineral density if your body does not make enough new bone.

The recommended total intake of calcium (diet plus supplementation) for adults is 1,000 to 1,400 mg per day. Dietary calcium sources include the following:

  • Dairy products such as milk, cheese, yogurt, and so on.
  • Vegetables in the Brassica family (broccoli, kale, cabbage).
  • Dark-green leafy vegetables (collards, dandelion greens, beet greens).
  • Some nuts and seeds.
  • Canned fish with bones.
  • Calcium in mineral water has been shown to support healthy bone-mineral density in some studies.
  • Dark chocolate

Sometimes calcium supplementation is necessary because you are not getting enough calcium from your diet. Your blood calcium levels might be fine, but this might mean that your body is getting calcium from your bones and storing it in your blood to supplement the deficit. If you have osteoporosis or osteopenia, it is a good idea to have your doctor order a 24 hour urine test for calcium. If you are not getting enough calcium from your diet and/or supplementation, it will become apparent from this test, regardless of what your blood levels are.

Many, if not most, persons fall short of the 1200-1500 mg recommendation for people over age 50. The recommendation might be due to a concern about calcification of soft tissues. However, calcification of soft tissues is not necessarily due to calcium intake, but to a lack of magnesium and vitamin K2.

The two most common supplement forms are calcium carbonate and calcium citrate.

  • Calcium carbonate requires stomach acid to be absorbed so people with low stomach acid should take a different kind of calcium.
  • Calcium citrate does not require stomach acid to be absorbed. Some people say that calcium citrate is more absorbable than calcium carbonate, but this might not be true. A randomized trial of 24 postmenopausal women found that calcium carbonate and calcium citrate produced equivalent increases in blood serum calcium levels over 24 hours.

Chelated forms of calcium such as Calcium lysinate might have superior bioavailability. Calcium lysinate showed superior bioavailability compared to both calcium carbonate and calcium citrate in a clinical trial.

Calcium microcrystalline hydroxyapatite (MCH) is extracted from animal bone. A randomized trial with 100 postmenopausal women found that MCH increased blood levels of calcium at a lower rate than either calcium citrate or calcium carbonate, but had an equivalent effect on bone turnover. Now there is a manufactured form of MCH called nano hydroxiapatite, which is vegan. There is already a toothpaste with nano hydroxyapetite. I think calcium supplements will soon follow if they have not already.

Note: When you consume calcium (through food, supplementation, or both), the amount absorbed into the body decreases as the intake increases. It is best to spread calcium intake, especially in supplemental form, over the day and to consume no more than 500 mg at a time.

If you are looking for a high-quality calcium supplement see Jarrow Formulas.

Protein

You should get at least 1 gram of protein per kilogram of body weight. One kilogram = 2.2 lbs. The following quote is from https://www.healthline.com/health/total-protein.

Protein makes up ~50% of bone volume and approximately one-third of its mass. It provides the structural matrix of bone, whereas calcium is the dominant mineral within that matrix. Collagen and a variety of noncollagenous proteins form the organic matrix of bone, so an adequate dietary protein intake would seem to be essential for optimal acquisition and maintenance of adult bone mass. Considerable attention has recently also focused on dietary protein’s role in the mature skeleton, prompted in part by an increasing interest in nonpharmacological approaches to maintaining skeletal health in adult life and later adult years.

Vitamin D3

Vitamin D3 has an important role in many physiologic functions such as muscle strength, immunity, inflammation, mood, and bone health. In bone health, vitamin D3 promotes the absorption of calcium from the gastrointestinal tract. Studies have suggested that:

  • Vitamin D3 and calcium confer the most benefit to bones when consumed together.
  • Without adequate vitamin D3 levels, only 10 to 15 percent of dietary calcium is absorbed.
  • When a person’s vitamin D3 stores are adequate, calcium absorption increases by 30 to 40 percent.

Dr. Dale Bredesen, an expert and pioneer on brain health, recommends a blood serum level of Vitamin D3 in the range of 50-80 ng/mL. This level is likely also good for your bones.

Magnesium and Vitamin D3

Magnesium is stored in bones, skeletal muscle, and soft tissues. In bones, magnesium is incorporated in the hydroxyapatite portion of the bone tissue where it contributes to bone tissue structure. Magnesium is also required for your body to make calcitonin–a hormone that reduces calcium in the blood and thereby inhibits bone breakdown.This process is explained further in Bone Remodeling and Bone Drugs.

In addition, magnesium promotes alkaline phosphatase activity (a critical enzyme for bone formation), vitamin D3 metabolism and activation to enhance calcium absorption in the GI tract. Magnesium also enables vitamin D3 to bind to its own transport protein to reach and be activated in the liver. Sources of dietary magnesium:

However, the U.S. National Health and Nutrition Examination Surveys show that most Americans consume less than the recommended intake of magnesium (310 to 420 mcg per day for adults). Consequently, magnesium supplementation might be necessary.

Most people who take supplemental calcium should also take supplemental magnesium. The recommended ratio of calcium to magnesium intake is about 2:1. You might want to consider your dietary intake of calcium and magnesium before deciding how much of each to supplement.

Some studies have found that magnesium in forms of aspartate, citrate, lactate, or chloride are absorbed more readily and are more bioavailable than magnesium oxide or magnesium sulfate. A small comparison study between chelated magnesium (magnesium bisglycinate) and magnesium citrate showed that magnesium citrate had better bioavailability than magnesium bisglycinate. However, magnesium glycinate is less likely to have bowel effects and might be tolerated better for some people than other forms.

Phosphorus

Calcium needs phosphorus to maximize its own strengthening benefits for strong bones and teeth. The daily recommended dose is 700 mg/day, and it is found in many foods. Side effects if you do not get enough include anxiety, loss of appetite, grumpiness, mood changes, trouble breathing, and sluggishness.

Example food sources of phosphorus:

  • Pork
  • Chicken
  • Organic meats
  • Fish
  • Cheddar cheese
  • Nutty spread
  • Corn
  • Broccoli
  • Sunflower and Pumpkin Seeds
  • Quinoa
  • Amaranth
  • Whole wheat
  • Beans and Lentils
  • Soy
  • Garlic
  • Nuts
  • Dark chocolate

For more information see:
Top 12 Foods That Are High in Phosphorus

Vitamins K1 and K2

Vitamin K is a group of fat-soluble vitamins with similar chemical structures. The two forms common in the human diet are vitamins K1 and K2. Both forms are important for blood clotting and bone health.

Vitamin K1 is mostly found in plant foods like green leafy vegetables and is about 75% to 90% of all vitamin K consumed by humans. Vitamin K2 is found in fermented foods, animal products, and is produced by gut bacteria. K2 has some subtypes called menaquinones (MKs). Their name is related to the length of their side chain, and range from MK-4 to MK13. The two main forms are MK-4 and MK-7.

  • MK-4 stays in the body for about 8 hours. It is found in pasteurized eggs, meats, and dairy, and has been shown to reduce fractures, but does not have the same circulatory benefits as MK-7.
  • MK-7 stays in the body for 24 hours or more. It is found in some fermented food, but is harder to find in the western diet. MK-7 has been shown to reduce bone loss, enhance bone formation, and reduce arterial stiffness by directing calcium to the bones and removing arterial plaque.

Vitamins K (K1 and K2) with D3 play a critical role in how your body deposits calcium into new bone. Bone building takes place after a series of chemical processes that result in carboxylated osteocalcin binding to calcium to build bone by depositing calcium into the hydroxyapatite of the bone. Carboxylated osteocalcin is essential for bone mineralization.

The Institute of Medicine has established no upper limit for vitamin K, stating that consumption of the vitamin is unlikely to cause adverse health effects.

MK-4 at 45 mg/day is a standard practice in Japan to support women’s bone health after menopause. Proponents of MK-4 cite studies conducted in Japan and other Asian countries that demonstrate benefits for bone health. In 2019, researchers compared daily MK-4 intakes of 5 mgs and 45 mgs. 5 mgs of MK-4 per day positively affected carboxylated osteocalcin levels, but 45 mgs offered no additional benefit.

MK-7 is widely available in dietary supplements in the United States. Recommended intakes are much lower than 45 mg per day. Although, it is usually taken between 45 mcg and 90 mcg per day, studies have evaluated intakes of up to 200 mcg per day as safe.

Probiotics and Bone Health

There are up to 1,000 species of bacteria in your gut microbiome that not only influence gastrointestinal and immune health, but are also involved in a number of mechanisms that affect bone health. A strong microbiome provides the following benefits to bone health:

Proven to reduce inflammation. The result of reduced inflammation is a strong digestive system where you get the maximum nutrition from the food you eat, which frees up more calcium, magnesium, vitamin K, D3, and other important bone minerals. Your body has the nutrients it needs to make strong, dense bones.

Increased synthesis of gut vitamins. Your gut uses probiotic bacteria to produce vitamins such as D, C, K, and folate. These vitamins are essential for managing the calcium in your body for forming bone.

Regulate your parathyroid hormone (PTH) levels. When your PTH levels go up, osteoclasts (see Bone Remodeling and Bone Drugs.) activate and break down bone. This process releases calcium into your blood and is intended to keep your blood calcium levels steady. Probiotics help maintain your PTH at steady levels, and this keeps osteoclast activity balanced. Balanced osteoclast activity helps your body maintain healthy calcium levels in your bones.

Best probiotics for osteoporosis:

  • L. Helveticus
  • L. salivarius
  • L. reuteri
  • B. Longum

Estrogen

Estrogen is a category of sex hormones that keeps cholesterol under control, protects bone health in women and men, and affects the brain, mood, heart, skin, and other tissues. Studies have found that estrogens play an important role in the regulation of bone mass and bone strength in humans by managing the activities of bone-forming osteoblasts and bone-reabsorbing osteoclasts. Not enough estrogen can cause the balance between bone formation and bone resorption to tip in favor of resorption. Over time this results in bone loss due to too much bone resorption.

A woman’s body produces the following 3 types of estrogen, each with a distinct function in the body:

  • Estradiol (E2). The most common estrogen in women of childbearing age, and used in hormone replacement therapy (HRT) for post-menopausal women. It is the most potent estrogen of the three. Its main function in a woman’s body is to mature and maintain the reproductive system.
  • Estriol (E3). The main estrogen during pregnancy. It is much less potent than estradiol. It promotes uterine growth and prepares a woman’s body for giving birth.
  • Estrone (E1). The only estrogen your body makes after menopause. It is much less potent than either estradiol or estrone. A woman’s body can metabolize estrone into estradiol.

Dr. Fishman provides detailed information about the complex effects of hormones in the human body in his book, Yoga for Osteoporosis.

Estrogen Receptors

Estrogen receptors are a group of proteins found inside cells that are activated by estrogen. Estrogen receptors are distributed throughout the body in the uterus, vagina, breast, pelvis, skin, bladder, urethra, bones, and brain, and play an important role in the overall health of these organs.

If your body is not producing enough estrogen, the receptors deactivate. However, if you start hormone replacement therapy (HRT), even if it is many years after your body stopped making estrogen, the receptors will slowly wake up to normal or nearly normal and resume their various roles.

Prescription HRT

When hormone replacement therapy is prescribed by a doctor for post-menopausal symptoms, the options are transdermal or oral. Transdermal administration can be patches, gels, or creams. Oral administration is a once-a-day pill. Either way, the estrogen can be derived from bioidentical estrogens or equine conjugated estrogens.

  • Bioidentical estrogens are chemically identical to the estrogen made by your body and come from plants such as soy, yams, sunflower seeds, poppy seeds, and other plants.
  • Conjugated equine estrogens are a mixture of the sodium salts of estrogen conjugates found in horses. They are available as preparations manufactured from pregnant mare urine, or as synthetic replications of the natural preparations.
  • Skin patches are administered at much lower doses than tablets. In most cases the tablets are 0.625 to 1 mg once a day. In contrast, the skin patches come in .025mg, .05mg, .075 mg, and .1 mg administered throughout the day.
  • A doctor typically orders estradiol blood level tests over a period time to determine the estradiol blood levels to figure out which patch or tablet strength produces the optimum estradiol blood level for a given person. An estradiol range of 30-60 pg/ml is considered optimal for increasing bone mass.

Some doctors prescribe a standard tablet dose such as 1 mg and then ask you how you are feeling the next time you come in. This is done for symptoms such as hot flashes, sleeplessness, depression, and so on, but is not helpful if you want help with osteoporosis where the symptoms are typically silent and revealed only upon having a DEXA scan or breaking a bone.

It can be difficult, but not impossible, to find a medical doctor who will prescribe estrogen, unless it’s only for short-term relief of post-menopausal symptoms. To use estrogen to prevent bone loss, you might have to find a functional, integrative, or naturopathic doctor. Also, if you are older and have been in menopause for some time, medical doctors don’t like to put you on it. It is unclear why.

Side Effects

It’s difficult to come up with a good list of side effects because the estrogen can be bioidentical or conjugated, and there are various modes of administration and strengths. In my opinion, bioidential hormone patches is the best way: lower doses and fewer, if any, side effects.

Second best, if cost is an issue, is bioidentical estrogen in tablet form. The drawback to the tablet is that you need a larger dose because it goes into your body through the gastrointestinal tract. Your body is made to absorb estrogen through skin tissue so transdermal estrogen is more efficient, works with a lower dose, and has fewer side effects.

Creams are transdermal too, but the estrogen doesn’t stay in your bloodstream as long. In my opinion, creams are fine for managing most menopause symptoms, but not for managing thinning bones.

DIM for Estrogen Metabolism

A good natural supplement is DIM. DIM helps with estrogen metabolism (whether you still produce your own or are supplementing) and can help prevent hormone-related cancers. DIM is found in cruciferous vegetables, and is also available as a supplement, so you don’t have to eat 2 lbs of broccoli every day. See DIM for Hormone Balance and Vibrant Health.

References

Strontium

Strontium is a mineral that can increase bone density as it is measured by the DEXA scan. In the U.S. it is available as an over-the-counter dietary supplement.

  • Strontium replaces calcium in the bone, but has a larger atomic weight. For every calcium atom replaced by strontium, the bone density appears larger, which artificially inflates the DEXA scan reading.
  • Strontium is not naturally abundant in humans and does not have an identified, unique biological role.
  • Strontium has potential safety risks and side effects that still need exploration.

The long-term effects of supplementing with strontium to increase DEXA scan results are not fully understood. It is not natural to bone in large amounts and might result in long-term problems, side-effects, and brittle bones. After you stop taking strontium, it can take a long time to leave your bone. For more information, see Smart Supplementing for Bone Health.

Strontium comes in several forms, as explained in this article: https://www.algaecal.com/algaecal-ingredients/strontium/. If you want to take strontium as a supplement, avoid strontium ranelate and make sure to take natural strontium salts (strontium citrate) instead. Strontium ranelate is a drug that is a synthetic form of strontium. People with kidney problems should not supplement with strontium, but should focus on foods that contain it instead. For a list of strontium food sources, see https://www.algaecal.com/algaecal-ingredients/strontium/strontium-rich-foods/.

Boron and Silica

Boron promotes bone building and resorption. It works best when taken in combination with other minerals so they can all work together to build strong bones. For a list of food sources, see https://www.algaecal.com/algaecal-ingredients/boron/boron-sources/.

Silica is an essential trace mineral for bone strength and density. It also strengthens skin, hair, and nails.

Chinese Herbs for Menopause Support

Chinese medicine recognizes the following herbs for managing menopausal symptoms:  Wild yam, black cohosh, Dong Quai (aka Dang Gui, Tang Kuei, Dang Gwi, and Qin Gui).

And these herbs help to restore youthfulness: He Shou Wu (pure form) or Shou Wu Formulation (gentler).

Exercise

Exercise is important to maintaining bone health. It places mechanical stress on the bones, which stimulates bone remodeling. See Bone Remodeling and Bone Drugs. The type of exercise you get needs to be weight bearing, but it can be low impact, high impact, or both. Qi Gong, Tai Chi, and Yoga described below are all weight bearing and low impact forms of exercise. For more information, see https://www.americansportandfitness.com/blogs/fitness-blog/high-impact-vs-low-impact-exercises and weight bearing activities.

Yoga

Over 80% of the people in the study reversed their bone loss and began to gain bone. No fractures or serious injuries of any kind were seen or reported in over 100,000 hours of people doing this yoga daily. Over 80% of them had osteoporosis or osteopenia when we started. Fewer had these conditions when we finished.”

– Yoga for Osteoporosis article by Dr. Fishman, in Art of Living, August 3, 2020

  1. View Loren Fishman Sequence 1: Twelve Poses vs. Osteoporosis on YouTube for free.
  2. Purchase Dr. Fishman DVD(s) with sequence 1 and/or 2 on his website (sciatica.org) near the bottom of the page. Sequence 3 is out, but there is no DVD yet. On the same page at the bottom, you can sign up for his newsletter to find out when he teaches sequences 1, 2, and 3 online.
  3. The following books have helpful information regarding how to use yoga to improve your bone health:
  4. See Yoga Sequences for Bone Health for a list of poses in the sequences referenced above.

Does Yoga Really Work?

Sequences 1-3 are listed at the bottom of this page. You can scroll to the bottom and then back up to see them.

Dr. Fishman Sequence 1 has been proven to work for building bone density. It works particularly well for spine and femur necks. Dr. Fishman Sequence 2 is proving to be effective while it is currently under study. His Sequence 3 will be under study soon. The other bone health sequences in my collection make no claims one way or the other. See also An Interview with Loren Fishman and Ellen Saltonstall.

Non-Response

Some participants in the Dr. Fishman studies do not respond to the yoga sequences with better bone density. I asked him if the size and weight of the person makes any difference to how some people’s bones respond to the yoga sequence. I was figuring that larger, heavier people place more weight bearing stress on their bones in the poses. As of this writing (1/28/2021), Dr. Fishman responds to the question as follows: There appears to be a relationship between family history and non-response, but even that is not very secure at this point. There is no relation between size and response-rate at this point.

This made me wonder if muscle strength, rather than the size of the person, might be the key. Perhaps placing an emphasis on different kinds of weight-bearing exercise would add more bone-making to the body’s bone remodeling process. See Bone Remodeling and Bone Drugs.

In addition, proper nutrition, as described in this post, is key to building and maintaining bone density and bone health. In fact, upping my calcium intake by a lot was the key for me. For others it might be adding or upping another nutrient, or getting off of proton pump inhibitors (PPIs).

Repetitive Stress Syndrome

Doing the same poses every day in the same order can eventually result in pain from repetitive stress. To avoid this problem, consider doing something like the following as recommended by Dr Fishman:

  1. Dr. Fishman Sequence 1 once or twice a week, but not on consecutive days.
  2. Dr. Fishman Sequence 2 once or twice a week, but not on consecutive days.
  3. Dr. Fishman Sequence 3 once or twice a week, but not on consecutive days.
  4. Attend an Iyengar yoga class once or twice a week to learn how to do the poses correctly.

Liz Larson in Dr. Fishman’s office suggests an alternative where you make Sequence 1 the primary focus and add different poses from Sequences 2 and 3 over a week in addition to the 12 in Series 1. This way you work on different poses in Sequences 2 and 3 as add-ons to a Sequence 1 basic practice.

Dr. Fishman recommends practicing 4 days a week, but there is no harm in practicing every day or nearly every day. You could also substitute a Dr. Fishman sequence with one of the other sequences in Yoga Sequences for Bone Health towards the end of this post.

Physical therapy can be helpful as well. I saw a physical therapist for back pain. When he found out I also had osteoporosis, he added some exercises to help my bones. I’m sure those plus the yoga, plus the upped calcium intake all played a part in my adding a good amount of bone desnity on my last DEXA scan.

Hold Times and Technique

The DVDs and books specify hold times that you can use as a guideline. Think of the hold times as goals that you might eventually reach. The sequences listed at the end of this document do not specify hold times, but because that section is compiled from sources that do, you can follow the guidelines in the original sources or start out with 20 to 30 second holds and build up to 40 to 60 seconds, if possible.
Participants in Dr. Fishman’s yoga vs. osteoporosis dose-response study are advised to hold poses for a minimum of 12 seconds and a maximum of 72 seconds. Holding for 30 seconds is a good goal to work toward. Muscular strength needs to be built to reach the point where you can hold the pose long enough to strengthen the bone. When stress is placed on a bone, the chemical markers in blood that indicate bone building is occurring are evident beginning at the 12 second mark and stop at 72 seconds.

Forward Bends

Forward bends are not recommended for people with bone loss in their spine. Dr. Fishman says there have been studies showing that the vertebrae can crunch against each other and crack during forward bends.
However, forward bends are likely safe for experienced yoga practitioners who know how to keep their spines straight and their upper backs forward as they go down. Proceed at your own risk, and never force yourself to go further than is comfortable. Stop immediately if it hurts. See link to article under Twists.

Twists

Dr. Fishman sequences have twists. Many doctors will tell you not to do twists if you have osteoporosis. However, Dr. Fishman says that in all of his years working with osteoporosis, he has never encountered anyone who hurt themselves doing a twist. It’s up to you whether you do twists or skip them, but if you do want to twist, never twist to the point of strain. Never force a twist and stop immediately if it hurts For more information, see: https://yogauonline.com/twist-or-not-twist-dr-loren-fishman-weighs-safe-yoga-postures-for-osteoporosis-new-york-times (includes information about forward bends).

Qi Gong and Tai Chi

Qi Gong is a mind-body exercise that was developed in ancient China and Tibet. Qi Gong uses meditation, breathing, and movement to increase energy, stimulate the body’s healing abilities, and includes spiritual and healing benefits. Tai Chi is a gentle, self-paced system of gentle physical exercise and stretching.

Physical Therapy

Physical therapists can provide exercises that help build bone. You can find someone local to you, or if you prefer online, see Margaret Martin at https://melioguide.com/. She specializes in physical therapy for prevention and treatment of osteoporosis. She provides safe and effective exercise programs for strong bones, perfect posture, better balance, and core strength.

Yoga Sequences for Bone Health

This section presents 5 sequences for improving bone health. Dr. Fishman Sequence 1 is proven to work for building bone density. It works particularly well for spine and femur necks. Dr. Fishman Sequence 2 is proving to be effective while it is currently under study. Sequence 3 will be under study soon. The Patricia Walden and Baxter Bell sequences make no claims one way or the other.

For guidelines when doing these poses, see the following sections in this document: Repetitive Stress Syndrome, Hold Times and Technique, Forward Bends, and Twists.

Dr. Fishman Sequences 1-3

Sequence 1.
See Sequence 1: Twelve Poses vs. Osteoporosis on YouTube.

  1. Vrksasana
  2. Utthita Trikonasana
  3. Virabadrasana 2
  4. Utthita Parsvakonasana
  5. Parivrtta Trkonasana
  6. Salabasana
  7. Setu Bhandasana
  8. Supta Padangusthasana 1
  9. Supta Padangusthasana 2
  10. Marichyasana 3
  11. Ardha Matsyndrasana
  12. Savasana
  1. Tree
  2. Triangle
  3. Warrior 2
  4. Side Angle
  5. Revolved Triangle
  6. Locust
  7. Bridge
  8. Reclined Hand to Foot 1
  9. Reclined Hand to Foot 2
  10. Straight-legged Twist
  11. Ben Knee Twist
  12. Relaxation (corpse)

Sequence 2.
Purchase Dr. Fishman DVD(s) Sequence 1 or 2 on sciatica.org. Scroll to the bottom of the page.

  1. Tadasana
  2. Utkatasana
  3. Virabhadrasana 1
  4. Ardha Chandrasana
  5. Ustrasana
  6. Vasisthasana
  7. Dandasana
  8. Urdhva Muka Paschimottanasana
  9. Arm Threading (see CD)
  10. Bharadvajasana
  11. Jathara Parivartanasana
  12. Savasana
  1. Mountain
  2. Chair
  3. Warrior 1
  4. Half Moon
  5. Camel
  6. Side Plank
  7. Staff
  8. Upward Legs Stretch
  9. Similar to Eagle pose (see CD)
  10. Twist with legs to one side
  11. Supine Twist
  12. Relaxation (corpse)

Sequence 3.

No DVD available yet. Sign up for Dr. Fishman’s newsletter at sciatica.org (scroll to the bottom of the page) to get email notices for his classes including his Yoga for Osteoporosis sequences. You can purchase any class through the newsletter,

  1. Modified Parsvottanasana
  2. Natarajasana
  3. Rajakapotasana
  4. Virabhadrasana 3
  5. Parivrtta Ardha Chandrasana
  6. Parivrtta Parsvakonasana
  7. Ardha Purvottanasana or substitute Purvottanasana
  8. Khumbhakasana
  9. Supta Padangusthasana 1
  10. Supta Padangusthasana 2
  11. Gomukasana
  12. Savasana
  1. Intense side stress modified to 90 degree angle only.
  2. Dancing Pose
  3. One-Legged King Pigeon
  4. Warrior 3
  5. Revolved Half Moon
  6. Revolved Side Angle
  7. Reverse Table Top or substitute up plank
  8. Plank
  9. Reclined Hand to Foot 1
  10. Reclined Hand to Foot 2
  11. Cow Face Pose on floor
  12. Relaxation (corpse)

Baxter Bell Sequence for Bone Strength

This sequence is available in Yoga for Healthy Aging by Baxter Bell and Nina Zolotow and also available on their Yoga for Healthy Aging blog. To find it, go to Holiday Presents, Day 1!, scroll down to the PDF, and then scroll to page 44 in the PDF.

  1. Bitilasana-Marjaryasana
  2. Dandayamana Bharmanasana
  3. Adho Mulkha Svanasana
  4. Khumbhakasana
  5. Tadasana
  6. Virabhadrasana 1
  7. Utthita Parsvakonasana
  8. Utkatasana
  9. Virabhadrasana 3
  10. Adho Mukha Svanasana
  11. Khumbhakasana
  12. Balasana
  13. Salabhasana
  14. Marichyasana 3
  15. Setu Bhandasana
  16. Savasana
  1. Dynamic Cat-Cow
  2. Hunting Dog
  3. Downward Dog
  4. Upwards Plank
  5. Mountain
  6. Warrior 1
  7. Extended Side Angle
  8. Powerful (Chair) Pose
  9. Warrior 3
  10. Down Dog (use foreamrs instead of hands)
  11. Plan from Knees (instead of toes)
  12. Child’s Pose
  13. Locust
  14. Sage’s Twist
  15. Bridge Pose
  16. Relaxation (corpse)

Patricia Walden Sequence

Important: Forward bends are not recommended for people with bone loss in their spine. If forward bends are a problem for you, you can skip them, modify the poses so that you keep a straight back with your chest forward, or substitute another pose. For more information, See Forward Bends in this document.

This sequence has the following forward bends:

  1. Uttanasana
  2. Parsvottanasana
  3. Prasarita Padottanasana
  1. Standing forward bend
  2. Intense side stretch
  3. Wide-angled forward bend
  1. Substitute Dandasana
  2. Bend to a 90 degree angle
  3. Bend to a 90 degree angle

This bone health sequence is available in the book Yoga for Healthy Bones by Linda Sparrowe. It is also available at A Sequence for Preventing/Reversing Bone Loss on the Yoga for Healthy Aging blog. See also Patricia Walden’s website for class information.

Natural Ways to Improve Bone Health

Bone Remodeling and Bone Drugs

Bone remodeling is the process by which your body makes and recycles bone. If you understand bone remodeling, you can more fully understand how bone drugs work and what they do in your body.

In this document
Bone Cells and Bone Remodeling
Osteoporosis Drugs
Antiresorptive Agents
(Fosamax, Binosto, Boniva, Actonel, Atelvia, Reclast,
Calcitonin, and estrogen)
Anabolic Agents
(Evenity, Forteo, Tymlos)

Bone Cells and Bone Remodeling

Bone remodeling is the continuous cycle of bone building and bone resorption. Bone building is the process by which your body adds new bone tissue to your skeleton, and bone resorption is the process by which your body removes (dissolves and assimilates) old bone tissue. Bone remodeling is a continuous process in your body that is regulated by calcium levels, the thyroid gland, and the parathyroid glands. It also requires proper nutrition.

The three types of cells in bone marrow that enable bone remodeling are osteoblasts, osteoclasts, and osteocytes. Each of these cells has a similar, but distinct, role in the health of the human skeleton. The main initiators of bone remodeling are 1) mechanical stress on the bones, and 2) hormonal controls that maintain calcium levels.

Mechanical stressors are running, walking, weight lifting, yoga, Qi Gong and other weight bearing activities that result in microscopic changes to the bone. If the microscopic changes are not repaired through bone remodeling, they get larger, and can over time cause a broken bone when under minimal stress.

Research shows that bone-building markers increase in your blood or urine in as little as 12 seconds of subjecting a bone to mechanical stress, and stop after 72 seconds. Bone markers are chemicals that show up in the blood and urine and can be identified through blood and urine testing.

Hormonal controls are managed by the thyroid and parathyroid glands.

  • Thyroid gland: The calcitonin cells (c-cells) in the thyroid gland produce calcitonin. Calcitonin reduces the calcium level in the blood and acts on the calcitonin receptors in bones to prevent the breakdown of bone. Both of these actions build bone (increase bone density).
  • Parathyroid glands: The parathyroid glands produce parathyroid hormones that stimulate osteoclasts to resorb (dissolve and assimilate) old bone cells and send the calcium stored in the resorbed bone cells into the bloodstream. When the blood-calcium level gets too high, the parathyroid gland stops producing parathyroid hormones. The drop in parathyroid hormones causes the blood calcium level to fall, which triggers bone building.

Hormones: Your body produces parathyroid hormone and vitamin D (vitamin D is a hormone) to help your body maintain calcium levels. Estrogen reduces the number of osteoclasts, which helps regulate the balance between osteoblasts and osteoclasts in favor of bone building.

  • Parathyroid hormone maintains calcium levels and stimulates bone formation and resorption.
  • Calcitrol (from vitamin D) stimulates the intestines to absorb enough calcium and phosphorus.
  • Calcium and phosphorus enable your body to build strong, healthy bones.

See Natural Ways to Improve Bone Health for information about nutrients, estrogen, and estrogen levels.

Osteoblasts (Bone Building)

Mechanical stressors stimulate osteoblasts to create collagen. Collagen is the organic component in bone and its role is to stimulate new bone growth and repair. Bone growth and repair strengthen the bones so they can handle the mechanical stresses put on them. Bones grow and remodel themselves based on the demand put upon them.

Osteoblasts move inside the bone, stick in the tissue, and turn into osteocytes (mature bone cells).

Osteocytes (Bone Building and Bone Resorption)

Mature osteocytes embedded in mineralized bone produce sclerostin. Sclerostin is a protein that inhibits bone formation and enhances the death of osteoblasts. Sclerostin is kept in balance as follows:

  • Bone Building: Parathyroid hormone and weight-bearing exercise both decrease sclerostin and increase IGF-1, a hormone associated with bone building.
  • Bone Resorption: Glucocorticoids (a class of steroid hormones made by the adrenal glands) enhance sclerostin, which enhances bone resorption.

Osteoclasts (Bone Resorption)

Osteoclasts manage the continuous break down and dissolution of mature (dead) bone cells. They dissolve the organic collagen and the inorganic calcium and phosphorus of old bone. Calcium and phosphorus, liberated by the breakdown of the mineralized bone, are released into the bloodstream. See Bone Resorption in Wikipedia.

Low amounts of any of the following tip the bone building and bone resorption ratio in favor of resorption: calcium, vitamin D, magnesium, phosphorus, vitamin K, probiotics, or estrogen levels.

  • Vitamin D promotes the absorption of calcium
  • Magnesium is needed for your body to make calcitonin
  • Calcium needs Phosphorus to maximize its ability to make strong bones
  • Vitamin K plays a critical role in how your body deposits calcium into new bone
  • Probiotics make your digestive system strong so your body can synthesize gut vitamins
  • Estrogen reduces the number of osteoclasts, which helps regulate the balance between osteoblasts and osteoclasts.

See Natural Ways to Improve Bone Health for information about the above nutrients and estrogen.

Osteoporosis Drugs

The next sections list common osteoporosis drugs by their classifications. It also explains what each classification of drugs does in your body, and for each drug, lists a few of the side effects for each drug. To get complete information on the side effects, you can look the drugs up on the web or talk to your doctor.

Antiresorptive Agents

Antiresorptive agents slow or block the resorption of bone by osteoclasts. Bone resorption is the process by which osteoclasts break down the tissue in bones and release the minerals, resulting in a transfer of calcium from bone tissue to the blood. 

Antiresorptive agents increase bone density using various strategies to slow bone resorption. This means old bone is kept and can result in brittle bones over time, which is why these drugs have a time limit on how long to take them. People with brittle bones are more likely to break their bones when they fall.

Dr. Fishman at Manhattan Physical Medicine says that yoga makes bones more pliable, which makes them more likely to withstand a fall. He also points out that smaller people don’t fall as far or take as much weight with them, which makes their bones less likely to break in a fall, especially if the bones are not brittle, but pliable.

In contrast, large people stimulate bone remodeling more easily because their size and weight put more demand on the bones.

See this eye-opening article on the FDA website, Possible Fracture Risk with Osteoporosis Drugs, and this one from Health Sciences Institute, Study Finds Popular Bone Drugs Actually Cause Fractures.

Bisphosphonates

Bisphosphonates inhibit bone resorption. They are combined with technetium 99m to enhance bone imaging for detecting bone problems such as osteoporosis and/or fractures. The main side effects for this class of drugs are gastrointestinal irritation such as stomach pain, heartburn, and acid reflux. Some of these drugs also have urinary tract side effects.

  • Alendronate (Fosamax) oral tablet or solution daily or weekly
  • Alendronte (Binosto) effervescent weekly tablet
  • Ibandronate (Boniva) monthly oral tablet
  • Ibandronate (Boniva) IV injection every 3 months
  • Risendronate (Actonel & Atelvia) daily, weekly, once a month, twice a month, oral tablet
  • Risendronate (Atelvia) weekly oral tablet
  • Zelodronic Acid (Reclast) yearly IV infusion

RANK Lignand (RANKL) Inhibitors

RANKL inhibitors prevent the development of osteoclasts, which are cells that break down old bone.

Calcitonin

Calcitonin is a hormone secreted by the Calcitonin cells (C cells) in the thyroid gland. It reduces calcium in the blood and acts on the calcitonin receptors in bones to prevent the breakdown of bone (keeps old bone around), which increases bone density.

Calcitonin is reserved for the treatment of postmenopausal osteoporosis in women when other treatments for osteoporosis are ineffective, not tolerated, or not desired. The FDA discourages its use, saying the risks of malignancy outweigh its benefits. Nasal side effects are common and blood calcium levels must be within the normal range before treatment begins.

  • Calcitonin (Fortical) daily nasal spray. Example side effects: nasal irritation, nose bleeds, runny nose, and sneezing.
  • Calcitonin (Miacalcin) injection. Example side effects: blurred vision chills or fever cough difficulty breathing difficulty swallowing.

Estrogens (Hormone Replacement Therapy)

Studies have found that in men and women, estrogens play an important role in the regulation of bone mass and bone strength by managing the activities of bone-forming osteoblasts and bone-resorbing osteoclasts. Not enough estrogen can cause the balance between bone formation and bone resorption to tip in favor of resorption, which over time results in bone loss. Estrogen reduces the number of osteoclasts, which helps regulate the balance between osteoblasts and osteoclasts. See Natural Ways to Improve Bone Health for more information about hormone replacement therapy (HRT).

  • Oral tablet once a day (multiple brands)
  • Transdermal patch once or twice a week (multiple brands)

Estrogen Agonists/Antagonists, aka SERMS

Selective Estrogen Receptor Modulators (SERMs) are agents that activate some estrogen receptors, but not others. This means they have an estrogen-like effect on target tissues such as bone, without affecting other tissues that have estrogen receptors. See Natural Ways to Improve Bone Health for more information about hormone replacement therapy (HRT) and estrogen receptors.

  • Raloxifene (Evista) daily oral tablet. Example side effects: bloody or cloudy urine, throat congestion, and chest pain.

Tissue-Specific Estrogen Complex (TSEC)

This type of bone drug pairs an estrogen or estrogens with a SERM (described above). The goal is to provide the clinical benefits of each component (estrogen and SERM) for improved tolerability. A TSEC that contains the SERM bazedoxifene and conjugated equine estrogens, such as Premarin, relieves hot flashes, improves vulvovaginal atrophy and its symptoms, and prevents loss of bone mass without stimulating the lining of the uterus (endometrium). Stimulating the endometrium might lead to endometrial cancer.

  • Estrogen/Bazodoxifene (Duavee) daily oral tablet. Example side effects: muscle spasms, nausea, vomiting, diarrhea, and indigestion.

Anabolic Agents

This is a group of synthetic testosterone derivatives with pronounced anabolic (building) properties, and relatively weak androgenic (male characteristic promoting) properties. Anabolic agents stimulate the growth and repair of body tissues in diseases or states that promote the wasting of tissue (such as osteoporotic bone loss).

Sclerostin Inhibitor

Sclerostin is made by bone tissue. Its role is to inhibit bone formation and enhance the death of osteoblasts (bone-forming cells). This type of drug inhibits sclerostin to encourage bone formation and prolong the life of osteoblasts.

  • Romosozumab-aqqg (Evenity) monthly or yearly injection. Example side effects: Fast heartbeat, skin rash, and chest tightness. See the NY Times article: Most Osteoporosis Drugs Don’t Build Bone. This One Does that explains the drug and carries the following notice at the bottom:

    This drug was approved only for postmenopausal women with a high risk of fracture, and will carry a warning on its label that it may increase the risk of heart attack or stroke, the F.D.A. said.

Parathyroid Hormone Analogs

Forteo and Tymlos are lab-made versions (analogs) of human parathyroid hormone (PTH). Both drugs are similar to the PTH that your body produces naturally. Forteo is also available as a generic drug called Teriparatide. Both medications are self-administered daily with an injection pen.

The drugs in this category both replicate the bone-producing effects of parathyroid hormone. These medications only work to build bone, so physicians will also recommend a bisphosphonate medication to decrease the rate that bone is destroyed to slow down your body’s natural rate of bone loss. This is so you don’t lose more bone than these drugs help you to build.

  • Teriaparatide (Forteo) daily injection. Example side effects: dizziness, nausea, headache, rapid heartbeat, fatigue, stomach pain, and vertigo. More serious but less common side effects include bone cancer, decrease in blood pressure, increase in blood calcium, and an increase in urine calcium.
  • Abaloparatide (Tymlos) daily injection. Example side effects: pain, nausea, and joint aches. More serious but less common side effects include bone cancer, increased calcium in the blood, worsening kidney stones, and a decrease in blood pressure.

For more information, see What is the Difference Between Tymlos and Forteo?

Bone Remodeling and Bone Drugs

Probiotics – Do you need to take them?

A thriving, diverse microbiome is key to overall good health because it supports your gastrointestinal health, immune system, and possibly your bones.

~ Your microbiome consists of the genetic material of all the microbes (bacteria, fungi, protozoa and viruses) that live on and inside your body. The two most important things about your gut microbiome are the number and variety of microbiota. ~

Today, many people use probiotic supplements, foods, and drinks to restore and maintain health in their gut microbiome. This is because probiotics balance microorganism levels in the intestines, lower the numbers of harmful bacteria, and boost the body’s immune system.

are probiotic Supplements necessary?

The short answer to whether probiotic supplements are necessary or not is probably not, unless you have chronic yeast-related infections (candidiasis) and/or digestive issues, were recently on antibiotics (especially if they were broad spectrum), spend all of your time indoors and/or don’t get enough exercise, or eat a lot of sugary foods, simple carbs, and sugary drinks. In these cases, a probiotic supplement could be an essential part of a recolonization plan to fix a compromised microbiome.

The gut microbiota are mostly sourced during a vaginal birth from the mother, and then from the environment and the kinds of foods you eat or are fed. Breast feeding instead of bottle feeding enables more microbiota from the mother to reach the infant.

Some people think that it’s important to get outdoors and a little dirty to maintain a robust microbiome of soil-based organisms (SBOs). While being outdoors and getting exercise is an important part of good health, SBOs, especially the supplements, are a controversial idea with experts on both sides of the issue of whether they are good for you or not. See the following references for both sides of the issue:

If you have a reasonably healthy lifestyle, but also have problems with chronic yeast infections and/or gut-related problems (for example, gas, bloating, constipation, diarrhea, and heartburn), consider whether your diet is too high in sugar, too low in nutrition, or includes too many simple carbs, fried foods, or fast foods.  Also consider whether you have too much stress in your life, and whether you are getting enough exercise and sleep.

To thrive, microbes must be welcomed into a hospitable environment, and the importance of diet and life style in creating and maintaining a healthy microbiome cannot be overemphasized. A hospitable microbiome environment is made up of a wide variety and a lot of friendly bacteria. Friendly bacteria keep bad bacteria in check because they secrete butyrates and fatty acids that clean out damaged cells and regulate your metabolism.

Antibiotics

The overuse or unneeded use of antibiotics upsets the microbiome balance in your gut because they kill both the good and the bad bacteria in your body. If you have to take antibiotics, try to get your doctor to order one that is not broad spectrum, but targeted to the specific problem bacteria. See The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing.

How to fix (Recolonize) your gut microbiome

There is no harm in supplementing  with probiotics especially if you have recently been on antibiotics, or feel that you need to recolonize your gut microbes. A recolonization plan includes:

  1. A good probiotic supplement
  2. Fermented foods such as sauerkraut, kimchi, probiotic yogurt, or probiotic kefir.
  3. Soluble fiber from foods such as asparagus, onions, apples, psyllium husk, black beans, lima beans, avocados, and brussel sprouts.
  4. Resistant starches, such as beans, peas, and lentils.

After your recolonization plan is complete, you don’t need to take probiotics every day, as long as you keep up a low-sugar, high soluble fiber diet, are not taking any more antibiotics, get regular exercise, and maintain low stress levels. In fact, making these lifestyle changes can help your gut microflora multiply and diversity more than a probiotic supplement by itself. Eventually, the lifestyle changes might be seen by experts as far more important than probiotic supplements.

A Few Findings from Various Studies:

Probiotics – Do you need to take them?

Polenta Pizza Crust

Jeffrey made this beautiful polenta crust pizza last night. Below is a recipe for a polenta pizza crust. For the topping, you can do whatever you want. The one he made last night had asparagus, zucchini squash, onions, mushrooms, and mozzarella cheese.

Make the Crust

This recipe is easy to make and very tasty. It takes about 60 to 75 minutes to make because the crust has to cool in the refrigerator for about 30 minutes before you cook it. The cooking time is about 20-30 minutes.

Ingredients

2 cups polenta
4 cups vegetable broth or 4 cups of water and 2 cubes of bouillon
1 Tbsp olive oil
1 tsp salt (optional)
1 tsp garlic powder (optional and unnecessary if you put garlic on the pizza)
1 tsp oregano
1 tsp basil
1/2 tsp parsley
1/4 tsp black pepper (optional)

Steps

  1. Over high heat, bring vegetable stock or water with bouillon cubes to a boil.
  2. Reduce heat to medium and add olive oil, salt, garlic powder, oregano, basil, parsley, and black pepper, or if you are using bouillon cubes, just add olive oil, salt, garlic powder, and black pepper.
  3. Whisk continuously while you pour in the polenta. Continue whisking for 3-5 minutes until smooth and thick, but not too thick.  You should still be able to stir the mixture.
  4. Put the polenta onto a rectangular cookie sheet by placing small  scoops in various locations on the sheet.  Spread the scoops evenly around the cookie sheet until it is completely covered and about 1/4″ to 1/2 ” thick. You can use a wet spoon, your hands, or a silicon spatula.
  5. Put the pan in the refrigerator for 25-35 minutes until it sets.
  6.  While the pan is in the fridge, preheat your oven to 475 degrees (F).
  7. Take the crust from the fridge and use the blunt side of a knife to cut it into 4, 6, or 8 squares.
  8. Bake the crusts until they are brown. Look underneath, and if the crusts are also brown underneath, you can take the pan out of the oven. If the crusts are not brown underneath, flip them and cook until brown.
  9. Take the pan out of the oven and add your toppings.
  10. Broil on low on the top rack until the cheese is brown and crispy. If you didn’t use cheese, then until the toppings are cooked and browned.
Polenta Pizza Crust

Climate Change in the Polar Arctic

By guest blogger, Jeffrey Pawlan.

The extent of the climate change in the Arctic Polar region is far more significant than reported in the general news. Richard Engel (NBC and MSNBC) reported that he was in Iceland 5 days ago and he stood on the very last remaining glacier in all of Iceland. It was melting so quickly that Engel thinks it too will be gone sometime next year.  Iceland may need to change its name!

In June, Monica and I went to the Arctic Polar region much further North and East of Iceland. We went to the Svalbard Island group which is due North of Scandinavia.  I have completed my photo editing and posted the final selection on the following page:

https://jeffreypawlanphotography.com/places/svalbard-the-polar-arctic-region

The beauty and the complete quiet were stunning but the very noticeable devastation to the region by the heat was very upsetting.  The only town in this island group is Longyearbyen on Spitzbergen. That large bay previously froze over every year so hard that ice tractors could safely drive over it for several months of the year.  The Director of the Svalbard museum told me in an interview that it has not frozen over at all for at least 8 years.  The buildings in Longyearbyen, like the buildings in the Alaskan Arctic, are all built on foundations drilled into the permafrost.  Now the permafrost has melted to a depth of more than a yard and the buildings are sinking and breaking apart. You will see in my photos that there is no permafrost at all in many of the other islands. This is extremely bad because the melted permafrost contains a great deal of methane and that gas is released in very large quantities in the heat of the summer. That did not happen at all when it was frozen year-round.

We saw very few animals and we saw starving reindeer.  I measured the air temperature at 80 degrees 10 minutes North and it was consistently 50 degrees F. The glaciers were melting at such a fast rate they will be gone within 40 years. The fast ice connected to the land was almost gone. It is breaking off and became sheets of sea ice which move around with the wind and the sea currents. Of course Russia is thrilled as they will soon not need to use their nuclear powered ice breakers to cross the North Pole to get to the Pacific side of Russia which is the East Siberian Sea and the Bering Sea.

Climate Change in the Polar Arctic

Helping My Cat, Ollie, with IBD

kittens021812

This is our cat Ollie (on the left in the photo) with his brother, Stan, when we first got them as kittens. They are litter mates born November 22, 2011, and your first question might be, “How on earth do you tell them apart?

Ollie, like his namesake Oliver Hardy, is a little larger than his brother, Stan (named for Stan Laurel), but sometimes we did mix them up and call one by the other’s name. As they got older, personality differences emerged that made it easier to tell them apart, but not always.

dsc_0526

As kittens, these boys did everything together: slept, ate, and went to the cat box together; cried for food together; got into mischief together; and sometimes, tried to climb into the refrigerator together.

In the photo on the right, Stan is in the wastebasket. Not sure which one or if both of them tipped the wastebasket and shredded the toilet paper roll. My guess is that it was a combined effort on all accounts.

Ollie Gets Sick

After two or three years, Ollie started to have difficulty passing stool and later started throwing up. Our vet at the time had us manage the stool problem by giving him a hairball remedy that he licked off my finger a couple of times a week, and put him on a prescription-only limited protein diet that he said would help with digestion. We put both cats on this program because it would be too difficult to try to feed them separate diets.

We also tried to get Ollie and his brother to drink more because the vet said that both cats were dehydrated. We did our best for awhile, but after a year or so, we started varying their diet with other high-quality non-prescription cat foods that were less expensive.

P1000116.JPG

Things seemed to go somewhat smoothly for a year or so until Ollie started to throw up, and the throwing up became more dramatic as time went on. The throwing up was preceded by distinct gurgling in his stomach and a tendency to drink a lot of water.

It got to the point where he would projectile vomit all of his stomach contents, whatever food and water was in there plus yellow bile from his gall bladder, all over the place. He would do this two or three times in different locations until he had emptied everything out.

For awhile he’d be in a daze where he couldn’t move at all, and then would slowly come out of it. Sometimes he lost his appetite and it would take several days before he would get back to his old self, only to repeat this cycle 3 weeks later.  Over time, it was every 2 weeks, and then every week or even more often than that. It was a challenge to keep him from losing too much weight.

We were very concerned and took him to a new vet, who did some blood tests, recommended we put him back on the prescription-only limited protein diet, suggested that he probably had food allergies and possibly pancreatitis. She referred us to a veterinary internist for further investigation.

Note: Prescription-only pet food is manufactured in certified clean facilities where each type has it’s own protected area so there is no cross-contamination. Some cats are so sensitive to products in their food that any cross-contamination from another food that contains an allergen can cause problems. Limited protein diets are much easier to digest for pets with food allergies.

Why are food allergies important? — you might ask. If a human or an animal eats foods that cause an allergic reaction in their body, their immune system turns on to fight the allergen as an invader. If the allergen is eaten every day, this can result in the immune system being on all of the time, which can lead to auto-immune diseases such as Irritable Bowel Disease (IBD).

IBD

The internist also did some blood tests, and recommended an ultrasound, which showed that his small intestine was completely enlarged. He diagnosed IBD  in the small intestine — not pancreatitis like the previous vet thought.

IMG_20180328_105744 (1).jpg
Ollie with his abdomen shaved for the ultrasound

He told us his small intestine will never go back to normal, but his throwing up could be managed with steroids, which he said work better in cats than in humans. He assured us that a cat can live 2 years or so on the steroids, and would have a higher quality of life for those 2 or so years because he wouldn’t throw up more than once a month.  If we do nothing, Ollie will throw up more and more, lose more and more weight, and waste away. He also said there was a chance that Ollie has cancer and wanted to do a surgical biopsy to rule out cancer.

After two consultations with the internist, we decided not to go with the steroids or the biopsy. The visits were expensive for us, very stressful for Ollie, and resulted in vomiting and general upset when he got home.

Also, the idea of pilling him every day sounded stressful for us and for him. Have you ever tried to pill a cat who wants absolutely nothing to do with being pilled? It can work for a few days or a week, but every day for two or so years? I just couldn’t imagine that working at all.

We then decided to stop taking him to the vet and go the natural route.

Vitality Science

After searching the web and reading reviews, we decided to contact Stephen Becker at Vitality Science. He was very helpful and patient, and answered all of our questions even though we likely asked the same ones a few times.

DSC_0529.JPGHe recommended which products to start with given our description of what Ollie was going through. After that, it took some experimentation to find exactly the right combination of products, the right dosages, and the right way to administer them — in their food or with a syringe.

Note:  Be very careful if you use a syringe. You need to aim it into their cheek to keep the solution from going into their lungs.

Stephen Becker helped us out as needed along the way. We initially tried two supplements that Stephen recommended that were applicable to Ollie’s condition, tried a few others that we thought would be good, and then settled on three.

Initial Supplements

DSC_0524.JPGIt became clear right away that using a syringe was not going to work with Ollie. He fought it tooth and nail and we knew the added stress was not doing him (or me) any good. So, we tried putting the supplements in their wet food. We started with  Super Pet Enzymes, which neither Ollie or Stan seemed to notice in the food.

Then, we added  EasyGo Original, which was to help Ollie with his constipation. Unfortunately, Ollie wanted nothing to do with this one, even though it had worked wonders on other cats and dogs. (The comparable product for dogs is EasyGo Dogs.)

So, we approached his constipation by continuing to give him the hairball remedy that he licks from my finger, and by adding a tablespoon of remineralized distilled water to all of their meals (2 wet and 2 dry) to keep them both hydrated. For 2 of the meals in a day, we mixed the the Super Pet Enzymes into the water and then put the wet or dry food on top.

It took some experimentation and help from Stephen to settle on the right dosage of the enzymes. It also took time for Ollie’s body to acclimate to the supplements. After starting with 1/2 tsp for both cats, we reduced it to about 1/4 tsp, and now we give them closer to 1/8 tsp once or twice a day.

Final Supplements

Because of Ollie’s sensitive stomach, we do not give them every supplement at each meal, but spread the dosing throughout the day over 4 separate small meals for both cats — curative for Ollie and preventative for Stan, who so far has not shown any IBD tendencies or any other problems.

In addition to the Super Pet Enzymes, we added  Pet Flora / Cat Probiotics to one meal a day. This one was tricky because too much or too often seemed to upset his stomach. To make it easy to give him a very small dose (much smaller than 1/8 tsp), I emptied the capsules into a small container with a top. When I want to use it, I press my  index finger into the powder and then swirl whatever sticks to my index into the water, then add the food on top. Since I have been dosing Ollie this way, the probiotics have not caused him an upset stomach.

Note: Comparable probiotic product for dogs is Pet Flora Dogs.

Sometime Later, Vitality Science added  Luxolite for Cats and Dogs to their product line. Being already familiar with this Bentonite clay and how good it is for many things, including digestion and removing toxins, we eagerly added it. The cats don’t seem to notice it in the food, and so I give them 1 tsp in each of 2 meals a day.

Menu

Breakfast

  1. 1 tablespoon remineralized distilled water swished around on a large plate.
  2. 1 teaspoon Luxolite for Cats and Dogs mixed into the water.
  3. 1/2 can wet food added on top of the water and divided into 2 portions on the large plate.

Lunch 

  1. 1 table spoon remineralized distilled water swished around on a large plate.
  2. 1/8 tea spoon Super Pet Enzymes mixed into the water.
  3. 1/4 cup dry food added on top of the water and divided into 2 portions on the large plate.

Dinner

  1. 1 tablespoon remineralized distilled water swished around on a large plate.
  2. 1 teaspoon Luxolite for Cats and Dogs mixed into the water.
  3. 1/2 can wet food added on top of the water and divided into 2 portions on the large plate.

Before Bed

  1. 1 tablespoon remineralized distilled water swixhed around on a large plate.
  2. One index finger of Pet Flora / Cat Probiotics mixed into the water.
  3. 1/4 cup dry food added on top of the water and divided into 2 portions on the large plate.

How Ollie is Doing Now

After nearly 2 years on the protocol, Ollie has stabilized on the above diet and Vitality Science supplements routine. His stomach still gurgles, but it often does not result in any vomiting. When he does vomit, he does not go into a daze, and gets back to eating the same day. He will have a reduced appetite and spend the afternoon sleeping and gurgling. This sometimes continue into the next day, but either way, he recovers his energy, appetite, and sweetness, and in reasonably short order, gets back to chasing Stan around. As of this writing, Ollie’s last vomit was just over 2 weeks ago.

hanging.jpg
Hanging with your bro. Stan on the left resting his head against Ollie’s back.

Reference

The following is an interesting article that discusses cat nutritional needs, including gut flora:

The carnivore connection to nutrition in cats by Debra L. Zoran, DVM, PhD, DACVM.

Helping My Cat, Ollie, with IBD

How I Minimized my Osteoarthritis Symptoms

In the Fall of 2016, I started experiencing pain, tingling, and numbness in my arms and hands. It was both sides from the shoulders all the way down to my fingertips. At night the tingling would wake me up after only a couple of hours of sleep. I would lie awake with so much discomfort, that I couldn’t go back to sleep for a long time.

When I woke up in the morning, I was unable to make a fist with my right hand for several hours. In fact the best I could do was bend my 5 fingers on the right hand a little bit. Left hand was better because it would almost close.

I also had *a lot* of trouble turning a door knob to open a door. Sometimes I couldn’t open a door at all because of the pain in my wrists. I couldn’t carry heavy bags with either hand, and the pain in my wrists prevented me from lifting anything even a little heavy.

I did the best I could with the discomfort by wearing a wrist and forearm brace to lift heavy oI bjects, to rest my forearms, wrists, and hands, or while on the computer. I also slept on two folded blankets at night to cushion my aching limbs so that I could stay asleep longer.

Doctors

I saw my primary care physician in April 2017 and after an examination, she told me that I had carpal tunnel syndrome, tendinitis, neuritis, and osteoarthritis. She added that over time and with some care, the carpal tunnel, tendinitis, and neuritis should go away, but the osteoarthritis will only get worse. The best I could do is slow it down, but it will never go away or improve.

In July 2017, I went to see a hand specialist, who took x-rays of both hands. I wanted to know for sure and absolute if I really have osteoarthritis. He said, yes, I definitely do, but not very much — yet. Overall, the bones in my hands looked healthy and strong except for the top joint in my right little finger that showed some wear causing my little finger to permanently bend at that joint. There were also a few cysts (signs of osteoarthritis) in both hands, but not much else.

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With rings on her fingers and bells on her toes  . . . .

I experienced a lot of pain given how good my x-rays looked, but the doctor said that was normal (I was skeptical).

He gave me a prescription for hand therapy. I asked him if after doing hand therapy for some time if I would be able to reduce the swelling in my fingers enough so that I could start wearing my rings again. He said that it is is very, very possible.

In August 2017 I retired from my job as a technical writer because I felt that being on a keyboard all day was at the root of my shoulder, arm, wrist, hand, and finger problems. This way, I would remove what I thought was the cause and focus on whatever cure I might be able to accomplish. I have to say I am very happy with the results so far.

In August 2018, I found that I could get my rings on my fingers again.

Yoga

I practice yoga every day, and have the book Yoga for Arthritis – The Complete Guide by Loren Fishman. The almost daily practice of hand therapy combined with my weekly yoga class, daily home yoga practice, and the advice in Dr. Fishman’s book, have helped so much that today my carpal tunnel, tendinitis, and neuritis have all resolved. My discomfort from osteoarthritis is now minimal and my dexterity has improved quite a lot.

Diet and Supplements

I also made a few changes to my diet towards a more anti-inflammatory diet, and adopted some herbs and supplements as suggested in Dr. Susan Blum’s book Healing Arthritis: Your 3-Step Guide to Healing Arthritis Naturally.

Hand Therapy

Hand therapy is wonderful. It strengthens your wrists, hands, and fingers, reduces the pain, and increases dexterity. To see results you have to do it every day (with only a few misses). At least that was the case for me.

Hand therapy consists of simple exercises for your wrists, hands, and fingers. Once you learn the exercises, it takes only a few minutes to do them all. I often do them while doing things like watching television, sitting in a waiting room, or watching a movie.

Hand exercises can help strengthen the muscles that support the hand joints. See Ten Ways to Exercise Hands and Fingers for some exercise suggestions.

Soaking your hands in warm water for ten minutes or so before beginning exercises can warm them up and increase flexibility.

Treating your hands with a warm paraffin wax bath can also be very helpful. Everything you need for a warm paraffin wax (tub and paraffin) can be purchased online or at many pharmacies. See The Best Paraffin Baths for Soothing Arthritis Aches and Pains.

An extra bonus of the hand therapy, is that my therapist custom made splints for my worst fingers. I had one made for my bent little finger on the right hand. You wear the splints at night to immobilize the finger(s) to reduce swelling. I also found they help straighten fingers that are not terribly bent.  I still use the one for my little finger daily to keep it straight and help maintain straightness even when I’m not wearing it. The finger is not perfect, but much straighter now than when I started.

Massage

Even though the hand therapist told me to be careful and gentle with my wrists, hands, and fingers and to not push myself, I found that gradually pushing my limits slowly over time helped to lessen the pain and increase flexibility and dexterity.

Instead of slowing down the progression of my symptoms, I experienced less and less pain and swelling over time, and my symptoms stopped flaring up. It seemed that from a symptoms standpoint, that I was actually getting better and not just slowing down the progression.

I massaged my hands with olive oil to which I added drop or two of oregano and thyme oil. That would be about 1/3 C olive oil with a drop or two each of oregano and thyme oil. Alternately, you could use a drop or two of just oregano or just thyme oil, or just use olive oil.  I personally found that adding the oregano oil was very soothing.

My body absorbed the oils very slowly, so I ended up massaging my wrists, fingers, and hands for a long time while watching TV (for example). I would gently press and massage where I felt pain until the pain gradually worked itself out. I would also flex my wrists, hands, and fingers in different ways until I felt a little pain, and gently held the position and/or massaged the  area. Gradually over a few days or a week or so I  managed to work the pain out and regain some flexibility and dexterity.

Dexterity

To further improve dexterity, do things like picking up and handling coins, counting change, or anything else that involves handling a number of small things. Experiment and see what works best for your particular situation.

How I’m doing Now

  • I can now sleep through the night without pain waking me up.
  • I do not need to sleep on top of folded blankets.
  • I can turn doorknobs and  open most doors unless the door itself is very heavy.
  • I can carry bags with my hands, although if they are really heavy, I have to use my arms and carry them against my torso.
  • I can make a complete fist with both hands first thing in the morning.
  • My wrists, hands, and fingers are still stiff, but the pain is now minimal.
  • Dexterity in my fingers is much better than it was, but not as good as before. At least not yet.
  • I can spend time on the computer keyboarding again (how else could I have written this?). I do have to limit the time because the stiffness creeps back the longer I keyboard. But, when I stop and stretch my hands, the discomfort recedes.
  • I use a large mouse when I keyboard. It’s large enough to comfortably support my hand without strain.
  • I have a much easier time handling small things like putting coins away and making change.

Going Forward

I plan to continue my program forever if that’s what it takes.  I believe I can continue to reduce the pain and stiffness, increase my manual dexterity, and make myself stronger in my hands, arms, and shoulders.

How I Minimized my Osteoarthritis Symptoms

Henna Hair to Natural Grey – The Steps

The goal is to get to where my hair grows out dark from the indigo, with some red highlights from the henna, and beautifully conditioned from the cassia. When I get to the last step, I will maintain that mix until all of the dark red underneath has been cut off. Then, I will stop using the mix and let the indigo and henna fade to gray little by little every time I wash my hair.

Even though henna is a permanent color, it should fade with the the semi-permanent indigo because I use so little henna with more indigo in Step 6. The goal is to have the indigo and henna fade together. We’ll find out how well that works when I get there.

To go from henna hair to natural gray, I changed the mix in the following steps:

1.   50 gms henna, 20 gms, cassia, 5 gms indigo: Completed 8/8/2018
2.   40 gms henna, 25 gms cassia, 10 gms indigo: Completed 8/25/2018
3.   30 gms henna, 30 gms cassia, 15 gms indigo: Completed 9/9/2018
4.   20 gms henna, 40 gms cassia + 15 gms indigo: Completed 9/25/2018
5.   10 gms henna, 50 gms cassia + 15 gms indigo: Completed 10/9/2018
6.   5 gms henna, 55 gms cassia + 15 gms indigo: Completed 10/24/2018
7.   Continue Step 6 until all dark henna hair grows out and has been cut off: Ongoing
8. 
 After 1 month, adjusted mix to 8-10 gms henna + 50 gms cassia + 15 gms indigo: Completed 11/24/2018
9.   
Continue Step 8 until all dark henna hair grows out and has been cut off: Ongoing
10. Fade to gray: 4/20/2020: Almost there.

Step 1

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50 gms henna, 20 gms, cassia, 5 gms indigo

Before doing Step 1, I went to my hair stylist, William Hopper at Custom Hair Styling in San Jose CA, and had him cut off 2 inches from the bottom.

The next day, after completing step 1 (see photo at left), my hair is about the same color, but the roots are a lighter orange/brown (not shown in the photo) that blend nicely with the rest of my hair. It is slightly more brown than burgundy from the addition of the indigo.

IMG_20180816_101245.jpgAfter washing my hair a couple of times over the next week, it is easier to see how my hair is starting to turn brown (see photo at left). At this point it still has some burgundy highlighting, which you can see in the middle of the photo.

The brown color comes from mixing henna with indigo.  You get a nice brown with red highlights.  Also, henna is brightest right after you apply it and gradually fades as you wash your hair. The indigo also slowly fades, which is where I want to  end up with light brown hair with the burgundy color grown out and cut off, at which point I can fade to gray.

Step 2

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40 gms henna, 25 gms cassia, 10 gms indigo

Looking a little darker, especially compared to the first picture in Step 1, after applying the Step 2 herbs (less henna and more indigo) to my hair.

Here is how it looks after two hair washings:

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Step 3

30 gms henna, 30 gms cassia, 15 gms indigo

Step-3

Getting lighter with a more even color.

 

 

 

After one washing it is slightly less red (more brown) and a more even color:

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Step 4

20 gms henna, 40 gms cassia + 15 gms indigo

IMG_9-26-2018Looking underneath you can see that the hair is getting darker with the henna to indigo ratio changing. Light coming in through a window makes the henna red seem stronger than it actually is.

 

Step 5

10 gms henna, 50 gms cassia + 15 gms indigo  – Completed 10/9/2018

Step 6

5 gms henna, 55 gms cassia + 15 gms indigo  –  Completed 10/24/2018

Hair is getting darker (less henna compared to the indigo), but the roots are lighter (less henna underneath). The goal now is to let it grow out until all the darker hair is cut off.

Step 10

Addendum (4/19/2020): After almost two years of letting it grow out, I do have a line between the colored and gray. The line isn’t that distinct and the colored part continues to lighten as it grows out. The protocol I outlined in the two posts about this didn’t go quite as I expected, but I am very happy with the outcome.

Henna Hair to Natural Grey – The Steps